· IL23 is a member of the IL12 cytokine family and, in addition to the IL12 related p40 subunit, it also has a unique p19 chain 12It is produced mainly by activated myeloid cells, endothelial and epithelial cells, and mediates signalling via its heterodimeric IL23 receptor complex, consisting of a unique IL23 receptor (IL23R) subunit paired with a common IL12Rβ1However, dysregulated IL23 production also promotes autoimmune inflammation 60, 61 IL23 was identified in 00 as a heterodimer composed of the IL12/23p40 subunit and a newly discovered p19 subunit that is exclusive to IL23 57 IL23 signals through aIL23 may constitute with IL17 an acute response to infection in peripheral tissues IL23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the JakStat signaling cascade, stimulates memory rather than naive Tcells and promotes production of proinflammatory cytokines
Schematic Representation Of Il 12 And Il 23 With Their Receptors And Download Scientific Diagram
